Abstract
FINELY divided silica produces fibrotic lesions when it is inhaled or injected into the lung. The mechanism by which silica exerts its pathogenic effects has not been established but it is probable either that it functions by absorbing some cell constituent onto surface silanol groups or that, after particles have been ingested by phagocytes, monosilicic acid which is produced when silica dissolves in the cytoplasm exerts the cytotoxic action. In either case silanol groups are involved.
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References
Schlipköter, H. W., Ministerprasident des Landes Nordrhein-Westfalen Landesamt für Forschung. Jahrbuch 1964, 451.
Holt, P. F., and Nasrallah, E. T., Nature, 211, 878 (1966).
Nash, J., Allison, A. C., and Harington, J. S., 210, 259 (1966).
Ikekawa, N., and Yoshiro, S., Pharmacol. Bull. Japan, 2, 400 (1954).
Schlipköter, H. W., and Brockhaus, A., Fortschritte der Staublungen- forschungen, 377 (1963).
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HOLT, P., LINDSAY, H. & NASRALLAH, E. Interaction of some Polyvinylpyridine Oxides with Polysilicic Acid and its relationship to their Ability to inhibit Silica Fibrosis. Nature 216, 611–612 (1967). https://doi.org/10.1038/216611a0
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DOI: https://doi.org/10.1038/216611a0
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