Abstract
THYMECTOMY of the newborn animal is known to be followed by a striking deficiency of the lymphocyte population1–3. Data concerning myelopoiesis are not consistent. In some cases, extensive extramedullary haemopoiesis was observed in the spleen of thymectomized mice4. An abnormal persistence and even increase of myeloid tissue in the spleen and lymph nodes of thymectomized opossum embryos has been described5. Furthermore, there was an increased ratio of immature to mature erythroblasts, not only in the spleen and lymph nodes, but also in the liver, bone marrow and submucosa of the small intestine. No abnormal extramedullary myelopoiesis has been reported in the thymectomized rats. A quantitative investigation6 did not reveal any change in the cell population of the bone marrow of rats after thymectomy, which was performed some weeks after birth, when the weight of the animals was about 70 g. Thymectomy is not likely to be very effective when it is performed so late after birth2.
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CORSI, A., GIUSTI, G. Cellular Distribution in the Bone Marrow after Thymectomy. Nature 216, 493–494 (1967). https://doi.org/10.1038/216493a0
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DOI: https://doi.org/10.1038/216493a0
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