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Carcinogenicity of Hydrazine and 1,1-Dimethylhydrazine for Mouse Lung

Nature volume 216, pages 375–376 (1967)Cite this article

Abstract

BOTH hydrazine itself and 1,1-dimethylhydrazine are known to be hepatotoxic1–5, but neither compound was investigated for carcinogenicity until Biancifiori and Ribacchi6 tested hydrazine sulphate as part of a study of the mechanism of carcinogenesis by the anti-tuberculous drug, isonicotinic acid hydrazide7,8. These workers reported the induction of pulmonary tumours in 100 per cent of twenty-two female Balb/C mice which survived daily oral treatment with 1.13 mg of hydrazine sulphate for 46 weeks (total dose of hydrazine sulphate, 283 mg).

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Authors and Affiliations

  1. Chester Beatty Research Institute, Fulham Road, London

    F. J. C. ROE, G. A. GRANT & D. M. MILLICAN

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  1. F. J. C. ROE
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  2. G. A. GRANT
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  3. D. M. MILLICAN
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ROE, F., GRANT, G. & MILLICAN, D. Carcinogenicity of Hydrazine and 1,1-Dimethylhydrazine for Mouse Lung. Nature 216, 375–376 (1967). https://doi.org/10.1038/216375a0

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