Abstract
THERE is still uncertainty about the cytological characteristics of stem cells, their production and kinetics. As far as pathology is concerned the acute leukaemias are characterized by the presence and multiplication of the youngest recognizable cells of each haemopoietic line; these are the blasts. The identity of the blasts and their histogenetic connexions with stem cells are not known, and the possibility that acute leukaemia blasts are stem cells has recently been raised1–3. These blasts are often similar to the normal parent cells of the various haemopoietic lines and can therefore be identified as myeloblasts, lymphoblasts or monoblasts. Sometimes, however, their features are even more undifferentiated and/or atypical, and thus the definitions stem cell leukaemia, haemocytoblastic acute leukaemia, acute histioleukaemia.
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GAVOSTO, F., PILERI, A., GABUTTI, V. et al. Non-self-maintaining Kinetics of Proliferating Blasts in Human Acute Leukaemia. Nature 216, 188–189 (1967). https://doi.org/10.1038/216188a0
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DOI: https://doi.org/10.1038/216188a0
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