Abstract
LYSOSOMES are subcellular particles in which several acid hydrolases of various specificities are localized. One of their main intracellular functions is to digest exogenous compounds taken up by the cell. The lysosomal system can be overloaded with substances which cannot be degraded, at least at a sufficient rate, by hydrolases1. This occurs in rat liver lysosomes2 and to some extent in kidney3 and spleen4 lysosomes after injection of ‘Triton WR-1339’, a non-ionic detergent. This compound is taken up by liver, kidney and spleen cells, and accumulates inside the lysosomes because it is not subjected to the lytic action of lysosomal enzymes. Accumulation causes increase in granular size and decrease in granular density.
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WATTIAUX, R., WATTIAUX-DE CONINCK, S. Influence of the Injection of ‘Triton WR-1339’ on Lysosomes of a Rat Transplantable Hepatoma. Nature 216, 1132–1133 (1967). https://doi.org/10.1038/2161132a0
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DOI: https://doi.org/10.1038/2161132a0
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