Abstract
STUDIES of the effects of microbeam ultraviolet light on growing tissue culture cells have shown that nucleolar RNA synthesis decreases rapidly but protein synthesis is either not affected1 or is decreased as a result of inhibition of nuclear RNA synthesis2. The influence of ultraviolet light energy on formation of macromolecules in more differentiated cells, however, has not been adequately studied. In the present study we examined the effects of heterochromatic ultraviolet light on RNA and protein synthesis in granular cells of human epidermis in vivo. These cells are differentiated epidermal cells which do not replicate, but do actively synthesize RNA and protein.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Takeda, S., Naruse, S., and Yatani, R., Nature, 213, 697 (1967).
Errera, M., Hell, A., and Perry, R. P., Biochim. Biophys. Acta, 49, 58 (1961).
Baden, H. P., and Pearlman, C., J. Invest. Dermatol., 43, 71 (1964).
Daniels, F., Brophy, D., and Lobitz, W. C., J. Invest. Dermatol., 37, 351 (1961).
Nix, T., Nordquist, R. E., and Everett, M. A., J. Ultrastruct. Res., 12, 547 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FUKUYAMA, K., EPSTEIN, W. & EPSTEIN, J. Effect of Ultraviolet Light on RNA and Protein Synthesis in Differentiated Epidermal Cells. Nature 216, 1031–1032 (1967). https://doi.org/10.1038/2161031a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/2161031a0
This article is cited by
-
Lysosomes and the Reactions of Skin to Ultraviolet Radiation**From the Division of Dermatology Cornell University Medical College, New York, New York 10021.
Journal of Investigative Dermatology (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.