Abstract
INCREASED excretion of pyruvate has been observed in the urine of diabetic humans1 and rats2 which could not be correlated with blood pyruvate concentrations. This suggested that the increased excretion of pyruvate in diabetes was caused by altered kidney metabolism which in some way reduced the reabsorption of pyruvate in the kidney tubule. To investigate this possibility the concentrations of pyruvate and the activities of pyruvate kinase and lactate dehydrogenase are here reported in the kidney of the alloxan-diabetic rat and compared with the liver in the same condition.
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References
Anderson, J., Comty, C. M., and Mazza, R., Lancet, ii, 1093 (1964).
Anderson, J., Coulson, R., and Tomlinson, R. W. S., J. Physiol., 189, 237 (1967).
Hohorst, H. J., Kreutz, F. H., and Bücher, T., Biochem. Z., 332, 18 (1959).
Marks, V., Clin. Chim. Acta, 6, 724 (1961).
Bücher, T., and Pfleiderer, G., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O. ), 1, 435 (Academic Press, New York, 1955).
Kornberg, A., in Methods of Enzymology (edit. by Colowick, S. P., and Kaplan, N. O. ), 1, 441 (Academic Press, New York, 1955).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Lamprecht, W., and Trautschold, I., Hoppe-Seyl. Z., 311, 245 (1958).
Williamson, D. H., Lund, P., and Krebs, H. A., Biochem. J., 103, 514 (1967).
Weber, G., Stamm, N. B., and Fisher, E. A., Science, 149, 65 (1965).
Weber, G., Lea, M. A., Fisher, E. A., and Stamm, N. B., Enzyme Biol. Clin., 7, 11 (1966).
Krebs, H. A., and Eggleston, L. V., Biochem. J., 94, 3c (1965).
Tanaka, T., Horano, Y., Morimura, H., and Mori, R., Biochem. Biophys. Res. Commun., 21, 55 (1965).
Takeda, Y., Inoue, H., Honjo, K., Tanioka, H., and Daikuhara, Y., Biochim. Biophys. Acta, 136, 214 (1967).
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COULSON, R., ANDERSON, J. Concentrations of Pyruvate, Pyruvate Kinase and Lactate Dehydrogenase in the Kidney of the Alloxan-diabetic Rat. Nature 215, 981–982 (1967). https://doi.org/10.1038/215981a0
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DOI: https://doi.org/10.1038/215981a0
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