Abstract
WHEN it was known that the excretion of hydroxyproline peptides in the urine was correlated with active growth, and varied in a characteristic way with age1–3, Alison et al.4 demonstrated that as a measure of growth the ratio of hydroxyproline : creatinine in a 24 h collection of urine was a great improvement on the hydroxyproline excretion/24 h, because the former eliminated to a great extent the effects of weight, and gave more consistent results for subjects of the same age. They found that the ratio fell in children between 1 and 5 yr, and then remained constant until puberty, after which it fell again to the adult level. Jasin et al.1 had already introduced the factor of surface area to try to eliminate the effects of size, and had found that the results obtained were constant between the ages of 1 and 10 yr.
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WHARTON, B., HOWELLS, G. & MCCANCE, R. Hydroxyproline Indices. Nature 215, 968 (1967). https://doi.org/10.1038/215968a0
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DOI: https://doi.org/10.1038/215968a0
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