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Growth Hormone and Carbohydrate Metabolism in vitro

Nature volume 215, pages 960–961 (1967)Cite this article

Abstract

ONE in vivo effect of growth hormone secreted by the anterior pituitary gland is to oppose the action of insulin in promoting the utilization of glucose in muscle (see ref. 1 for earlier references), an effect which is almost certainly of physiological significance2,3. Nevertheless, no satisfactorily reproducible effect of growth hormone in vitro on carbohydrate metabolism has been described. Rather surprisingly Park et al.4 observed that the addition of growth hormone in vitro to diaphragm from the hypophysectomized rat stimulates the uptake of glucose, that is, growth hormone exerts an insulin-like action in this system. This observation has been confirmed5 but is not reproducible with diaphragm from intact rats (see ref. 6 for further references). The amount of growth hormone added to diaphragm in vitro in these experiments was 1 µg/ml. or more.

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References

  1. Young, F. G., Rec. Prog. Hormone Res., 8, 471 (1953).

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  2. Roth, J., Glick, S. M., Yalow, R. S., and Berson, S. A., Science, 140, 987 (1963).

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  3. Luft, R., Cerasi, E., Madison, L. L., von Euler, U. S., Dalla Casa, L., and Roovete, A., Lancet, ii, 254 (1966).

  4. Park, C. R., Brown, D. H., Cornblath, M., Daughaday, W. H., and Krahl, M. E., J. Biol. Chem., 197, 151 (1952).

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  5. Manchester, K. L., and Young, F. G., J. Endocrinol., 18, 381 (1959).

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Author notes

  1. G. BOLODIA: Haile Selassie fellow on leave of absence from the Haile Selassie I University, Addis Ababa, Ethiopia.

Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge,

    G. BOLODIA & F. G. YOUNG

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  1. G. BOLODIA
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  2. F. G. YOUNG
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BOLODIA, G., YOUNG, F. Growth Hormone and Carbohydrate Metabolism in vitro. Nature 215, 960–961 (1967). https://doi.org/10.1038/215960a0

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