Abstract
THE passage of macromolecules through living membranes is facilitated by cationic forms of proteins1 and by histones, protamine and alkaline polyaminoacids as demonstrated by Ryser and Hancock2. Generally, the cell membrane surface is considered to carry a net negative charge, a property which should be especially pronounced in the case of many tumour cell surfaces3. Alterations reported in the permeability of cell membranes may be dependent on changes in membrane surface charges, caused by the adsorption of large cations. I have demonstrated that similar effects are produced by polycations on negatively charged artificial protein membranes.
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References
Chapman-Andresen, C., C.R. Trav. Lab. Carlsberg, 33, 73 (1962).
Ryser, H. J.-P., and Hancock, R., Science, 150, 501 (1965).
Ambrose, E. J., James, A. M., and Lowick, J. H. B., Nature, 177, 576 (1956).
Benesch, R., and Benesch, R. E., Proc. US Nat. Acad. Sci., 44, 848 (1958).
Delaville, M., Delaville, G., and Delaville, J., Ann. Pharmacol. Franc., 12, 109 (1954).
Johnson, R. H., J. Pharmaceutical Sci., 54, 327 (1965).
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LARSEN, B. Increased Permeability to Albumin induced with Protamine in Modified Gelatine Membranes. Nature 215, 641–642 (1967). https://doi.org/10.1038/215641a0
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DOI: https://doi.org/10.1038/215641a0
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