Abstract
THE term circadian was introduced by Halberg1 to describe a recurring sequence of events with a cycle of approximately 24 h, and the present knowledge of human circadian rhythms has been reviewed recently by Mills2. The circadian periodicity of a large number of constituents of blood, plasma, and urine has been described. Although a diurnal periodicity of whole blood amino-acids in man, in which concentrations at 2000 h were consistently greater than those at 0800 h on the same day, has been noted in this laboratory3, there were insufficient sampling times to establish a circadian pattern. A circadian periodicity of serum amino-acids in growing chickens4 and whole blood tryptophan in mice5 has been reported. We report here a circadian periodicity of whole blood and serum amino-acids in healthy adults.
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FEIGIN, R., KLAINER, A. & BEISEL, W. Circadian Periodicity of Blood Amino-acids in Adult Men. Nature 215, 512–514 (1967). https://doi.org/10.1038/215512b0
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DOI: https://doi.org/10.1038/215512b0
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