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Formation of Prothrombin Converting Activity

Nature volume 215, pages 248–251 (1967)Cite this article

Abstract

After measurement of the conversion of prothrombin to thrombin in a purified system, a model has been constructed for the kinetics of the formation of prothrombin converting activity. In the model phospholipid provides a surface on to which coagulant factors bind.

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References

  1. Macfarlane, R. G., Nature, 202, 498 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Davie, E. W., and Ratnoff, O. D., Science, 164, 1310 (1964).

    Article  ADS  Google Scholar 

  3. Breckenridge, R. T., and Ratnoff, O. D., J. Clin. Invest., 44, 302 (1965).

    Article  CAS  Google Scholar 

  4. Jobin, F., and Esnouf, M. P., Biochem. J., 102, 666 (1967).

    Article  CAS  Google Scholar 

  5. Denson, K. W. E., The Use of Antibodies in the Study of Blood Coagulation, 2 (Blackwell Scientific Publications, Oxford, 1967).

    Google Scholar 

  6. Esnouf, M. P., and Jobin, F., Biochem. J., 102, 660 (1967).

    Article  CAS  Google Scholar 

  7. Esnouf, M. P., and Williams, W. J., Biochem. J., 84, 62 (1962).

    Article  CAS  Google Scholar 

  8. Williams, W. J., and Esnouf, M. P., Biochem. J., 84, 62 (1962).

    Article  Google Scholar 

  9. Yin, E. T., Thromb. Diath. Haem., 12, 307 (1964).

    Article  CAS  Google Scholar 

  10. Schwert, G. W., and Takenaka, Y., Biochim. Biophys. Acta, 16, 570 (1965).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Nuffield Department of Clinical Biochemistry, Radcliffe Infirmary, Oxford

    H. C. HEMKER, M. P. ESNOUF, P. W. HEMKER, A. C. W. SWART & R. G. MACFARLANE

  2. Laboratory of Coagulation Biochemistry, Hematology Section, Department of Internal Medicine, University Hospital, Leyden

    H. C. HEMKER, M. P. ESNOUF, P. W. HEMKER, A. C. W. SWART & R. G. MACFARLANE

Authors
  1. H. C. HEMKER
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  2. M. P. ESNOUF
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  3. P. W. HEMKER
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  4. A. C. W. SWART
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  5. R. G. MACFARLANE
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HEMKER, H., ESNOUF, M., HEMKER, P. et al. Formation of Prothrombin Converting Activity. Nature 215, 248–251 (1967). https://doi.org/10.1038/215248a0

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