Abstract
THERE is evidence1,2 that the distributions of chondroitin sulphate and keratansulphate in both articular and costal cartilage are different and change with age. The concentration of keratansulphate has been shown to increase with distance from the periphery of the cartilage using ‘Alcian Blue’ (8GX, I.C.I. Ltd.) in graded concentrations of magnesium chloride, according to the “critical electrolyte concentration” technique3, with or without hyaluronidase digestion. In mature human articular cartilage, chondroitin sulphate is predominantly territorial while keratansulphate is characteristically inter-territorial, except in the deepest zones (adjacent to the calcified layer) of older tissue, where keratansulphate is localized close to the chondrocyte.
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STOCKWELL, R., SCOTT, J. Distribution of Acid Glycosaminoglycans in Human Articular Cartilage. Nature 215, 1376–1378 (1967). https://doi.org/10.1038/2151376a0
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DOI: https://doi.org/10.1038/2151376a0
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