Abstract
THE use of proteins as carriers of cytotoxic groups has been put forward on several occasions, based on indications that some specificity of uptake is thereby achieved. Busch and Greene1 have shown that administration of radioactive albumin leads to the selective incorporation of radioactivity into tumours compared with other host tissues. Experimental evidence has also been advanced to show that radioactivity is localized selectively in tumours after administration of anti-fibrin antibody labelled with iodine-131 (ref. 2) and of similarly labelled fibrinogen3. This effect was more marked in the case of transplantable tumours than for spontaneous tumours but the results obtained provide a sound experimental basis for the use of this protein as a vehicle for the preferential introduction of cytotoxic agents.
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WADE, R., WHISSON, M. & SZEKERKE, M. Some Serum Protein Nitrogen Mustard Complexes with High Chemotherapeutic Selectivity. Nature 215, 1303–1304 (1967). https://doi.org/10.1038/2151303a0
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DOI: https://doi.org/10.1038/2151303a0
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