Abstract
BIOCHEMICAL studies have shown that aryl sulphatase is concentrated in lysosomal fractions of liver1,2. This can now be confirmed cytochemically because hydrolytic enzymes other than acid phosphatase can be identified at the ultrastructural level. Histochemical methods of producing electron-dense enzyme reaction product at the sites of localization of E.600-resistant esterase2, and aryl sulphatase3, will provide important new information on the rapidly enlarging concept of lysosomes4,5. de Duve6 stressed the importance of developing these cytochemical methods for a wide spectrum of lysosomal enzymes. It is to be hoped that these may to some extent augment acid phosphatase as lysosomal markers.
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ROWDEN, G. Lysosomal Aryl Sulphatase in Mouse Kidney and Liver. Nature 215, 1283–1284 (1967). https://doi.org/10.1038/2151283a0
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DOI: https://doi.org/10.1038/2151283a0
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