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Uptake of Selenite labelled with Selenium-75 by Human Leucocytes in vitro

Nature volume 215, pages 1091–1092 (1967)Cite this article

Abstract

PREVIOUS work (reviewed in ref. 1) has shown that after the injection of selenite labelled with selenium-75 ( SeO 3 − − ) into animals radioactivity is incorporated into the proteins of various tissues. Recent studies in our laboratory2 have demonstrated that in humans selenite is rapidly taken up by the liver, kidneys and by malignant tumours. Analyses of both normal and tumour tissues have indicated that the selenium is bound to tissue protein by a covalent linkage. We have investigated the mechanism by which inorganic selenium is taken up by human cells.

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Author information

Authors and Affiliations

  1. Radioisotope Laboratory, Veterans Administration Hospital, San Francisco

    RALPH R. CAVALIERI, R. DICKARD & G. L. SEARLE

  2. Radioactivity Research Center, and Department of Radiology, University of California Medical Center, San Francisco

    K. G. SCOTT

Authors
  1. RALPH R. CAVALIERI
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  2. R. DICKARD
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  3. G. L. SEARLE
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  4. K. G. SCOTT
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CAVALIERI, R., DICKARD, R., SEARLE, G. et al. Uptake of Selenite labelled with Selenium-75 by Human Leucocytes in vitro. Nature 215, 1091–1092 (1967). https://doi.org/10.1038/2151091b0

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  • DOI: https://doi.org/10.1038/2151091b0

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