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Possible Mode of Action of a Naturally Occurring Cardiotonic Substance in Mammalian Tissue

Nature volume 214, pages 1352–1354 (1967)Cite this article

Abstract

A CARDIOTONIC substance which can be extracted from ox spleen has been described by Cobbin and Thorp1–3. Methods of purification and some of the chemical properties of this material have also been described by Temple, Thorp and Gillespie4. The active material has not yet been obtained in crystalline form, but it has been purified to such an extent that solutions containing 5 μg/ml. of such material produce a powerful stimulant action on isolated hypodynamic preparations of mammalian cardiac muscle in vitro. This substance is not unique to ox spleen because it has been isolated from human spleen, human blood and from tissues of other species.

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References

  1. Cobbin, L. B., and Thorp, R. H., Nature, 180, 242 (1957).

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Author notes

  1. R. H. THORP

    Present address: Department of Pharmacology, University of Sydney, Sydney, N.S.W.

Authors and Affiliations

  1. Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York

    K. S. LEE & R. H. THORP

Authors
  1. K. S. LEE
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  2. R. H. THORP
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LEE, K., THORP, R. Possible Mode of Action of a Naturally Occurring Cardiotonic Substance in Mammalian Tissue. Nature 214, 1352–1354 (1967). https://doi.org/10.1038/2141352a0

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  • DOI: https://doi.org/10.1038/2141352a0

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