Abstract
THE work of Lucy, Dingle and Fell1, Fell and Dingle2 and Ali3 points to a major involvement of lysosomal enzymes, particularly cathepsins (such as B and D), in chondrolysis. It seems likely that when these proteolytic enzymes are released from chondrocytes, their endopeptidase activity instigates a chain of catabolic events, involving a variety of hydrolases. These workers have shown that the degradation of the intercellular protein—polysaccharide matrix of cartilage demonstrated biochemically, was paralleled by a loss of metachromatic staining of the latter.
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References
Lucy, J. A., Dingle, J. T., and Fell, H. B., Biochem. J., 79, 500 (1961).
Fell, H. B., and Dingle, J. T., Biochem. J., 87, 403 (1963).
Ali, S. Y., Biochem. J., 93, 611 (1964).
Sylvén, B., and Malmgren, H., Acta Radiol., suppl., 154 (1957).
Holmberg, B., Cancer Res., 21, 1386 (1961).
Sylvén, B., and Bois-Svensson, I., Cancer Res., 25, 458 (1965).
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POOLE, A., WILLIAMS, D. In vivo Effect of an Invasive Malignant Rat Tumour on Cartilage. Nature 214, 1342–1343 (1967). https://doi.org/10.1038/2141342a0
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DOI: https://doi.org/10.1038/2141342a0
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