Abstract
A RECENT report from this laboratory1 showed that cephaloridine, a semi-synthetic cephalosporin, is hydrolysed by the β-lactamases from a variety of Gram-negative bacteria. The present investigation was undertaken as an extension of the previous one, to determine the lability of three other cephalosporins, cephalosporin C, cephalothin and cephaloram, to such β-lactamases.
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References
Hamilton-Miller, J. M. T., Smith, J. T., and Knox, R., Nature, 208, 235 (1965).
Datta, N., and Kontomichalou, P., Nature, 208, 239 (1965).
Hartley, B. S., and Kilby, B. A., Biochem. J., 50, 672 (1952).
Datta, N., and Richmond, M. H., Biochem. J., 98, 204 (1965).
Smith, J. T., and Hamilton-Miller, J. M. T., Nature, 197, 976 (1963).
Fleming, P. C., Goldner, M., and Glass, D. G., Lancet, i, 1399 (1963) ; Benner, E. J., Micklewait, J. S., Brodie, J. L., and Kirby, W. M. M., Proc. Soc. Exp. Biol. and Med., 119, 536 (1965).
Hamilton-Miller, J. M. T., and Smith, J. T., Nature, 201, 999 (1964).
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HAMILTON-MILLER, J. Hydrolysis of Cephalosporins by β-Lactamases from Gram-negative Bacteria. Nature 214, 1333–1334 (1967). https://doi.org/10.1038/2141333a0
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DOI: https://doi.org/10.1038/2141333a0
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