Abstract
Titration of a series of closely related β,β-dialkylglutarimide homologues with each other, and against a series of depressant drugs, provides evidence that stimulation and depression can be initiated at the same sites in the central nervous system.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Butler, T. C., Pharm. Rev., 2, 121 (1950).
Featherstone, R. M., and Muehlbaecher, C. A., Pharm. Rev., 15, 97 (1963).
Laycock, G. M., and Shulman, A., Nature, 200, 849 (1963). Shulman, A., Proc. Roy. Austral. Chem. Inst., 31, 41 (1964).
Laycock, G. M., Shankly, K. H., Shulman, A., and Wright, R. D., Med. J. Austral., 2, 866 (1964).
Laycock, G. M., Shulman, A., and Wright, R. D., Austral. J. Exp. Biol. Med. Sci., 43, 771 (1965).
Shulman, A., Laycock, G. M., and Henry, J. A., Nature, 208, 568 (1965).
Shulman, A., and Laycock, G. M., Intern. Congr. Physiol. Sci., twenty-third, Tokyo, 1965, Asbracts of papers, 535.
Shulman, A., and Laycock, G. M., Austral. J. Exp. Biol. Med. Sci., 36, 347 (1958).
Paton, W. D. M., Proc. Roy. Soc., B, 154, 21 (1961).
Lu, G., Ling, J. S. L., and Krantz, J. C., Anesthesiology, 14, 466 (1953).
Van Poznak, A., and Artusio, jun., J. F., Toxicol. App. Pharmacol., 2, 363 374 (1960).
Kapila, K., and Arora, R. B., J. Pharm. Pharmacol., 14, 253 (1962).
Frank, G. B., and Sanders, H. D., Brit. J. Pharmacol. Chemother., 21, 1 (1963).
Green, A. F., Ruffell, G. K., and Walton, E., J. Pharm. Pharmacol., 6, 390 (1954).
Braenden, O. J., Eddy, N. B., and Halbach, H., Bull. WHO., 13, 937 (1955).
White, R. P., and Westerbeke, E. J., Exp. Neurol., 4, 317 (1961).
Dashputra, P. G., Sharma, M. L., Jagtap, M. K., Khapre, M. D., and Rajapurkar, M. V., Arch. Intern. Pharmacodyn., 160, 106 (1966).
Heuser, G., Ling, G. M., and Buchwald, N. A., Arch. Neurol., 13, 195 (1965).
Schneider, J. A., and Sigg, E. B., Ann N.Y. Acad. Sci., 66, 765 (1957).
Chen, G., and Bohner, B., J. Pharmacol. Exp. Ther., 123, 212 (1958).
Guth, P. S., and Spirtes, M. A., Intern. Rev. Neurobiol., 7, 231 (1964).
Shulman, A., and Laycock, G. M., The Pharmacologist, 8, 183 (1966).
Shulman, A., Laycock, G. M., and Buchanan, A. S., Third Intern. Pharmacol. Cong., São Paulo, 1966, Proc. Symp. on Physico-chemical Aspects of Drug Action (edit. by Ariens, E. J.) (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAYCOCK, G., SHULMAN, A. Action of Drugs in the Central Nervous System. Nature 213, 995–998 (1967). https://doi.org/10.1038/213995a0
Issue Date:
DOI: https://doi.org/10.1038/213995a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
