Abstract
THE basic functions of cell DNA are priming of DNA synthesis and priming of RNA synthesis. The radiation damage of the first is believed to be closely related to mutant formation and cell reproduction, and that of the second to genetic determination and regulation of intra-cellular metabolic processes. Recent investigations of these basic functions of DNA resulted in profound changes in the existing research practice and directed the development of radiation biochemistry of DNA from an almost purely phenomenological ground to a more causal approach. Although a relatively clear picture of cell molecular biology does exist, conflicting results are still obtained about the activity of the DNA primer, so far as its radiosensitivity against ionizing radiation is concerned.
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ROBEV, S., MARINOVA, Z. X-Radiation Sensitivity of DNA—Ability to form Specific Molecular Hybrids with Isologous mRNA. Nature 213, 935 (1967). https://doi.org/10.1038/213935a0
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DOI: https://doi.org/10.1038/213935a0
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