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Neoplastic Transformation of Rat Embryo Cells by Simian Papovavirus SV40

Abstract

SV40 virus manifests its oncogenic action only in hamsters1 and in mastomys2. There are, however, reports of its transformation in vitro of cells of hamsters3, mice4, rabbits4, pigs4, cows5, monkeys6 and humans7. The purpose of our investigation was to determine whether the SV40 virus possesses the ability to transform rat cells in vitro.

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ALTSTEIN, A., VASSILJEVA, N. & SARYCHEVA, O. Neoplastic Transformation of Rat Embryo Cells by Simian Papovavirus SV40. Nature 213, 931–932 (1967). https://doi.org/10.1038/213931a0

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