Abstract
WE have recently reported that the administration of penicillamine (β,β-dimethylcysteine) results in a marked accumulation of soluble collagen in the skin of rats1. Ultra-centrifugal analysis of this thermally denatured material indicated that it consists almost exclusively of strands of α-collagen2. The pattern obtained appeared to be identical to that observed after the administration of lathyrogenic compounds such as β-aminopropionitrile3. In addition to the changes in solubility, animals treated with penicillamine also manifested a decrease in the tensile strength in the intact skin and in healing wounds1.
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References
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Nimni, M. E., du Guia, E., and Bavetta, L. A., J. Invest. Dermatol., 47, 156 (1966).
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NIMNI, M., GERTH, N. & BAVETTA, L. Reversibility of a Penicillamine Induced Defect in Collagen Aggregation. Nature 213, 921–922 (1967). https://doi.org/10.1038/213921a0
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DOI: https://doi.org/10.1038/213921a0
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