Abstract
THE essential role of vitamin B6 (used as a group name to include pyridoxine, pyridoxal and pyridoxamine) in maintaining the proper function of the central nervous system has been established1. Mental retardation, hyperirritability, and convulsive seizures are manifestations of deficient vitamin B6 metabolism. The similarity of the clinical syndrome of phenylketonuria suggests some malfunction of vitamin B6. Results of our studies on experimental phenylketonuria in rats indicate that inhibition of B6 function contributes to the pathogenesis of phenylketonuria.
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HOONG LOO, Y., RITMAN, P. Phenylketonuria and Vitamin B6 Function. Nature 213, 914–916 (1967). https://doi.org/10.1038/213914a0
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DOI: https://doi.org/10.1038/213914a0
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