Abstract
THERE have been many attempts to adapt influenza virus to growth at lower temperatures. For many viruses such as polio1–3, Japanese oncephalitis4 and measles5, a relationship has been observed between virulence and the ability to grow at lower temperatures, and this has been used in the selection of attenuated variants.
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References
Dubes, G. R., and Chapin, M., Science, 124, 586 (1956).
Sabin, A. B., First Internat. Conf. on Live Poliovirus Vaccines, 14 (Washington, 1959).
Plotkin, S. A., Norton, T. W., Cohen, B. J., and Koprowski, H., Proc. Soc. Exp. Biol. and Med., 107, 829 (1961).
Rohitayodhin, S., and Hammon, W., J. Immunol., 89, 589 (1962).
Hozinski, V. I., Seibel, V. B., Pantelyeva, N. S., Mazurova, S. M., and Novikova, E. A., Acta Virologica (English ed.), 19, 20 (1966).
Maassab, H. F., Proc. U.S. Nat. Acad. Sci., 45, 1035 (1959).
Eagle, H., J. Exp. Med., 102, 37 (1955).
Lwoff, A., and Lwoff, M., C.R. Acad. Sci. (Paris), 248, 1725 (1959).
Lwoff, A., Proc. Fifth Intern. Conf. Poliomyelitis, 13 (Copenhagen, 1961).
Smorodintsev, A. A., Cellular Biology of Myxovirus Infections, 333 (Little, Brown and Co., Boston, 1964).
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MAASSAB, H. Adaptation and Growth Characteristics of Influenza Virus at 25° C. Nature 213, 612–614 (1967). https://doi.org/10.1038/213612a0
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DOI: https://doi.org/10.1038/213612a0
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