Abstract
A 5.5 Å electron density map of ribonuclease has been obtained by X-ray diffraction using five isomorphous derivatives. One of the cystine residues is identified by means of a chemically modified protein and, using this residue as a starting point, likely positions are found for the other three. Using 2′-cytidylic acid as an inhibitor the active region of the molecule is found to lie in a cleft. An approximate arrangement of the polypeptide chain in the ribonuclease molecule is suggested. The preparation of the derivatives is described on page 562.
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An erratum to this article is available at https://doi.org/10.1038/213754a0
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AVEY, H., BOLES, M., CARLISLE, C. et al. Structure of Ribonuclease. Nature 213, 557–562 (1967). https://doi.org/10.1038/213557a0
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DOI: https://doi.org/10.1038/213557a0
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