Abstract
LITTLE information is available about the variation in concentration of bile acid in serum in health and disease. This is mainly a result of methodological difficulties which result from the solubility of bile acids which closely resembles that of other lipids. Serum extracts prepared according to previous techniques often contain small quantities of lipid material which cause errors in the assay of bile acids1. Attempts to separate these interfering substances are often associated with considerable losses of bile acids. These difficulties explain discrepancies in values for the concentration of normal bile acid in serum which have been reported to range between 0 and 60 mg/ml.2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Osborn, E. C., and Wootton, I. D. P., J. Clin. Pathol., 17, 156 (1964).
MacIntyre, I., and Wootton, I. D. P., Ann. Rev. Biochem., 29, 635 (1960).
Frosch, B., and Wagener, H., Klin. Wschr., 42, 901 (1964).
Frosch, B., Arzneimittel-Forsch., 15, 178 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FROSCH, B., WAGENER, H. Quantitative Determination of Conjugated Bile Acids in Serum in Acute Hepatitis. Nature 213, 404–405 (1967). https://doi.org/10.1038/213404a0
Issue Date:
DOI: https://doi.org/10.1038/213404a0
This article is cited by
-
Effects of cholesterol feeding to maternal rats on metabolism of cholesterol and bile acids in the dams and their offspring
Lipids (1988)
-
Glucuronidated and sulfated bile acids in serum of patients with acute hepatitis
Digestive Diseases and Sciences (1986)
-
Total plasma bile acid concentration in chronic hepatitis and cirrhosis; Fasting values and effect of intraduodenal bile salt administration
Klinische Wochenschrift (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
