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Mechanism of Radiation-induced Granulocytosis

Abstract

AN early and transient rise in the number of circulating neutrophilic granulocytes is known to occur in the blood of various mammals, including man, after exposure to radiation1–5. Neither the aetiology of this radiation effect, however, nor the source of the mature neutrophils has been established. The evidence discussed in the present communication suggests that the granulocytosis is caused by the release of one or more pharmacologically active biogenic amines, which mobilize large intravascular reservoirs of mature neutrophils.

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References

  1. Minot, G. R., and Spurling, R. G., Amer. J. Med. Sci., 168, 215 (1924).

    Article  Google Scholar 

  2. Patt, H. M., Smith, D. E., and Jackson, E., Blood, 5, 758 (1950).

    CAS  PubMed  Google Scholar 

  3. Stodmeister, R., Sandkuhler, S., and Fliedner, M. T., Proc. Second United Nations Intern. Conf. on the Peaceful Uses of Atomic Energy, 22, 238 (Geneva, 1958).

    Google Scholar 

  4. Bacq, Z. M., and Alexander, P., Fundamentals of Radiobiology, second ed. (Pergamon Press, 1961).

    Google Scholar 

  5. Gidali, J., and Feher, I., Blood, 23, 27 (1964).

    CAS  PubMed  Google Scholar 

  6. Veninga, T. S., and de Boer, J. E., Intern. J. Rad. Biol., 6, 501 (1963).

    CAS  Google Scholar 

  7. Bertelli, G., Falta, W., and Schweiger, O., Zeitschr. f. klin. Med., 71, 23 (1910).

    Google Scholar 

  8. Hortling, H., Acta Med. Scand., Suppl., 201 (1947).

  9. Bierman, H. R., Kelly, K. H., Cordes, F. L., Byron, R. L., Polhemus, J. A., and Rappoport, S., Blood, 7, 683 (1952).

    CAS  PubMed  Google Scholar 

  10. Gordon, A. S., Siegel, C. D., Dornfest, B. S., Handler, E. S., and LoBue, J., Trans. N.Y. Acad. Sci., 23, 39 (1960).

    Article  CAS  Google Scholar 

  11. Bierman, H. R., Byron, R. L., Kelly, K. H., Cordes, F., White, L. P., and Littman, A., Blood, 8, 315 (1953).

    CAS  PubMed  Google Scholar 

  12. Vejlens, G., Acta Path. Microbiol. Scand., Suppl., 33 (1938).

  13. Athens, J. W., Haab, O. P., Raab, S. O., Mauer, A. M., Ashenbrucker, H., Cartwright, G. E., and Wintrobe, M. M., J. Clin. Invest., 40, 989 (1961).

    Article  CAS  Google Scholar 

  14. Athens, J. W., Raab, S. O., Haab, O. P., Mauer, A. M., Ashenbrucker, H., Cartwright, G. E., and Wintrobe, M. M., J. Clin. Invest., 40, 159 (1961).

    Article  CAS  Google Scholar 

  15. Page, I., Physiol. Rev., 38, 277 (1958).

    Article  CAS  Google Scholar 

  16. Maloney, M. A., and Patt, H. M., in Haemopoiesis, Ciba Foundation Symposium (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 262 (J. and A. Churchill Ltd., London, 1960).

    Google Scholar 

  17. Athens, J. W., Ann. Rev. Physiol., 25, 195 (1963).

    Article  CAS  Google Scholar 

Download references

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RIXON, R., BAIRD, K. Mechanism of Radiation-induced Granulocytosis. Nature 213, 388–389 (1967). https://doi.org/10.1038/213388a0

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