Abstract
THERE has been some investigation of the in vitro transformation of cultured mammalian cells by adenovirus type 121–4. There is, however, only one report about the reproducibility of the phenomenon and the malignancy of the transformed cells. Transformed cells have never been examined for the presence of tumour antigen. A pathological investigation showed that the target cells of adenotumours were undifferentiated Schwann cells or mantle cells of the peripheral nervous system, which correspond to glial cells in the central nervous system5. We have observed earlier and more consistent transformation than has been reported previously, by the use of dispersed cells of the brain tissues of newborn hamsters. Preparation of the cells, the incidence of transformation and the biological characteristics of the transformed cells are described briefly in this communication.
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YAMANE, I., KUSANO, T. In vitro Transformation of Cells of Hamster Brain by Adenovirus Type 12. Nature 213, 187–188 (1967). https://doi.org/10.1038/213187a0
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DOI: https://doi.org/10.1038/213187a0
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