Abstract
THE involution of lymphoid tissue which follows administration of corticoids to animals could be a result of more rapid cell destruction or inhibition of an anabolic process. An increase in ribonuclease after injection of corticoid has been shown in corticoid-sensitive P1798 lymphosarcoma1, and in rat thymus2. This change is measurable 6 h or more after administration of cortisol. Enhanced ribonuclease activity could result in diminished protein synthesis.
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HOLLANDER, V., GORDON, C. & HOLLANDER, N. Effects of Corticoid Injection and of Adrenalectomy on in vitro Amino-acid Incorporation into Microsomes of P1798 Lymphosarcoma. Nature 213, 1036–1037 (1967). https://doi.org/10.1038/2131036a0
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DOI: https://doi.org/10.1038/2131036a0
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