Abstract
THE theory that injured skeletal muscle can regenerate by the formation of new cells although still disputed1 has strong support2–4. New muscle fibres are held to develop from multinucleate “myotubes” which are formed either by the budding of damaged muscle fibres or more probably by the fusion of mononuclear cells which have been termed “myoblasts”5–8. Walker insists that myoblasts multiply solely by mitotic division and derives them from injured adult muscle cells by dedifferentiation. Later cytoplasmic differentiation occurs mainly in myotubes and in these nuclear division is no longer seen. Others have claimed that myoblasts originate in connective tissue cells in or near the site of injury. It occurred to us, however, that like leucocytes and phagocytic histiocytes9 these muscle precursors could be carried in the circulation to injured areas from a central source, for example, the lymphoid tissues or bone marrow.
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BATESON, R., WOODROW, D. & SLOPER, J. Circulating Cell as a Source of Myoblasts in Regenerating Injured Mammalian Skeletal Muscle. Nature 213, 1035–1036 (1967). https://doi.org/10.1038/2131035a0
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DOI: https://doi.org/10.1038/2131035a0
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