Abstract
SEVERAL investigators1–4 have demonstrated RNA synthesis in normal and leukaemic lymphocytes by extraction of RNA from intact cells. To gather more information about RNA synthesis in human leukaemic leukocytes, experiments were designed to characterize nuclear RNA sedimentation patterns. Particular emphasis was placed on the comparison of nuclear RNA synthesis in cells derived from patients with chronic granulocytic leukaemia to those from patients with chronic lymphocytic leukaemia. These leukaemic cell types were chosen for investigation as examples of readily accessible human neoplastic cells of relatively low grade malignancy which appear to originate from two distinct haematopoietic cell lines.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Silber, R., Unger, K. W., and Grooms, R., Nature, 205, 1211 (1965).
De Bellis, R. A., and Marks, P. A., Proc. Amer. Assoc. Cancer Res., 4, 14 (1963).
Cline, M. J., and Fundenberg, H. H., Science, 150, 1311 (1965).
Rubin, A. D., and Cooper, H. L., Proc. U.S. Nat. Acad. Sci., 54, 469 (1965).
Dounce, A. L., in The Nucleic Acids (edit. by Chargaff, E., and Davidson, J. N.), 2, 93 (Academic Press, New York, 1955).
Salzman, N. P., Shatkin, A. J., and Sebring, E. D., J. Mol. Biol., 8, 405 (1964).
Bray, G., Anal. Biochem., 1, 279 (1960).
MacKınney, jun., A. A., Stohlman, F., and Brecher, G., Blood, 19, 349 (1962).
Hiatt, H. H., J. Mol. Biol., 5, 217 (1962).
Cooper, H. L., and Rubin, A. D., Science, 152, 516 (1966).
Henshaw, E. C., Revel, M., and Hiatt, H. H., J. Mol. Biol., 14, 241 (1965).
Revel, M., and Hiatt, H. H., Proc. U.S. Nat. Acad. Sci., 51, 810 (1964).
Kuff, E. L., and Humer, W. C., Biochemistry, 5, 959 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TRYFIATES, G., LASZLO, J. Nuclear RNA Synthesis in Human Leukaemic Cells. Nature 213, 1025–1027 (1967). https://doi.org/10.1038/2131025a0
Issue Date:
DOI: https://doi.org/10.1038/2131025a0
This article is cited by
-
Gesteigerte Interferonproduktion von Leukocyten in vitro bei chronischer myeloischer Leukämie
Klinische Wochenschrift (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.