Abstract
WE have already presented evidence that the capacity of pertussis vaccine to enhance antibody formation in mice to unrelated protein antigens is labile to heat and therefore, contrary to the view of many workers, cannot be attributed to the heat-stable endotoxin of the pertussis organism1. We postulated that the protective antigen is not only capable of sensitizing mice to histamine but may also be responsible for this typical adjuvant effect associated with pertussis vaccine. We further proposed that the autonomic nervous system may be involved in an enhancement of the immune response in mice mediated by pertussis. The object of this communication is to describe certain experiments designed to determine the validity of these postulations.
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PIERONI, R., LEVINE, L. Further Studies on the Adjuvant Principle of Pertussis Vaccine for the Mouse. Nature 213, 1015–1017 (1967). https://doi.org/10.1038/2131015a0
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DOI: https://doi.org/10.1038/2131015a0
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