Abstract
THE mechanism of the anti-inflammatory action of non-steroid anti-phlogistics has not yet been fully explained, and further information is required. In our studies of the biochemical properties of derivatives of 1,2-diphenyl-3,5-dioxopyrazolidine which possess anti-inflammatory activity and have an oxoalkyl group in position 4 of the pyrazolidine nucleus1, we have investigated their influence on fibrinolysis, using the method of von Kaulla2. We compared the following three derivatives of diphenyldioxopyrazolidine, which have been used clinically, with indomethacin and salicylic acid.
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References
Musil, V., Brunová, B., and Němeček, O., Collect. Czech. Chem. Commun., 29, 1669 (1964).
von Kaulla, K. N., J. Medic. Chem., 8, 164 (1965).
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ROUBAL, Z., NĚMEČEK, O. Activation of Fibrinolysis by Derivatives of Diphenyldioxopyrazolidine. Nature 212, 861 (1966). https://doi.org/10.1038/212861a0
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DOI: https://doi.org/10.1038/212861a0
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