Abstract
HISTONES and protamine are associated in vivo with nucleic acids. The effect of these basic proteins on the infectivity of Semliki Forest virus and its ribonucleic acid (RNA) was investigated under physiological conditions in order to obtain a model of viral replication in vivo. Viral RNA has a low infectivity when assayed under physiological conditions and is rapidly destroyed by RNase in animal sera1 and at the cell surface2.
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CONNOLLY, J. Effect of Histones and Protamine on the Infectivity of Semliki Forest Virus and its Ribonucleic Acid. Nature 212, 858 (1966). https://doi.org/10.1038/212858a0
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DOI: https://doi.org/10.1038/212858a0
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