Abstract
APPROXIMATELY 60 per cent of the total body serotonin (5-hydroxytryptamine) in the rat is present in the gastrointestinal tract1, and rises in the argentaffin cells2 which lie deep in the crypts of Lieberkühn3. The intestinal content of serotonin increases in mice after treatment with several antibiotics4,5, and there is a significantly higher concentration of serotonin in the ileum of germ-free chicks than of control birds6. Similar findings have been reported for rats, mice and chicks7, but it also appears that polymyxin B depletes bowel serotonin levels in the rat when treatment with the drug is continued for more than three days8. We report here the concentration of serotonin in the bowel mucosa of rats pretreated with Sulphamerazine.
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References
Erspamer, V., Experientia, 10, 471 (1954).
Benditt, E. P., and Wong, R. L., J. Exp. Med., 105, 509 (1957).
Bloom, W., and Fawcett, D. W., Textbook of Histology (W. B. Saunders and Co., Philadelphia, London, 1962).
Stacey, R. S., and Sullivan, T. J., J. Physiol., 137, 63 P (1957).
Sullivan, T. J., Brit. J. Pharmacol., 16, 90 (1961).
Phillips, A. W., Newcomb, H. R., Smith, J. E., and Lachapelle, R., Nature, 192, 380 (1961).
Beaver, M. H., and Wostmann, B. S., Brit. J. Pharmacol., 19, 385 (1962).
Telford, J. M., and West, G. B., J. Pharm. Pharmacol., 12, 254 (1960).
Quay, W. B., Life Sci., 4, 379 (1965).
Thompson, J. H., Irish J. Med. Sci. (in the press).
Linkswiler, H., Baumann, C. A., and Snell, E. E., J. Nutrit., 43, 565 (1951).
Jones, H. L., and Combs, G. F., Poult. Sci., 30, 920 (1951).
Gal, E. M., and Drewes, P. A., Proc. Soc. Exp. Biol. and Med., 110, 368 (1962).
Ory, E. M., and Yow, E. M., J. Amer. Med. Ass., 185, 273 (1963).
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THOMPSON, J., CAMPBELL, L. Influence of Sulphamerazine on Gastrointestinal Serotonin in the Normal Sprague–Dawley Rat. Nature 212, 850–851 (1966). https://doi.org/10.1038/212850a0
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DOI: https://doi.org/10.1038/212850a0
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