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X-ray-induced Mutations in Extracellular Phage

Abstract

IONIZING radiation produces mutations in a wide variety of living organisms, but its effectiveness as a mutagenic agent for extracellular virus particles is uncertain1–4. We investigated the mutagenic effects of ionizing radiation on free virus particles using the sensitive screening system provided by rII mutants of bacteriophage T4 (ref. 5). In this report, results will be described which show that r+II reverse mutations in T4B rII phage can be induced by X-irradiation of aqueous suspensions of the phage.

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BROWN, D. X-ray-induced Mutations in Extracellular Phage. Nature 212, 1595–1596 (1966). https://doi.org/10.1038/2121595a0

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