Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Gonadotrophin-inhibiting Action of Certain Carbohydrates

Nature volume 211, pages 975–976 (1966)Cite this article

Abstract

A GONADOTROPHIN-INHIBITING substance has been reported to occur in the urine of children1 and adults2,3 and in certain samples of human serum4. It inhibits the action of human chorionic gonadotrophins (HCG) and luteinizing hormone (LH), but is ineffective against the action of follicle-stimulating hormone (FSH). This communication reports the observation of certain similar effects using N-acetyl-D-neuraminic acid (D-NANA)—a constituent of both HCG and FSH, and using the related compound N-acetyl-D-mannosamine (D-NAM).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Soffer, L. J., Futterweit, W., and Salvaneschi, J., J. Clin. Endocrinol., 21, 1267 (1961).

    Article  CAS  Google Scholar 

  2. Soffer, L. J., Salvaneschi, J., and Futterweit, W., J. Clin. Endocrinol., 22, 532 (1962).

    Article  CAS  Google Scholar 

  3. Soffer, L. J., and Fogel, M., J. Clin. Endocrinol., 24, 651 (1964).

    Article  CAS  Google Scholar 

  4. Reiss, M., Pearse, J. J., Davis, R. H., Hillman, J. C., and Sideman, M. B., J. Endocrinol., 29, 83 (1964).

    Article  CAS  Google Scholar 

  5. Butt, W. R., Crooke, A. C., Cunningham, F. J., and Evans, A. J., Biochem. J., 79, 64 (1961).

    Article  CAS  Google Scholar 

  6. Cunningham, F. J., J. Endocrinol., 24, 215 (1962).

    Article  CAS  Google Scholar 

  7. Brunetti, P., Jourdian, G. W., and Roseman, S., J. Biol. Chem., 237, 2447 (1962).

    CAS  Google Scholar 

  8. Ladman, A. J., and Soper, E. H., Anat. Rec., 145, 332 (1963).

    Google Scholar 

  9. Adams-Mayne, M., and Ward, D. N., Endocrinology, 75, 333 (1964).

    Article  CAS  Google Scholar 

  10. Kathan, R. H., Winzler, R. J., and Johnson, C. A., J. Exp. Med., 113, 37 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, University of Birmingham,

    S. M. AMIR & S. A. BARKER

  2. East Birmingham Hospital, Birmingham, 9

    W. R. BUTT & A. C. CROOKE

Authors
  1. S. M. AMIR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. A. BARKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. R. BUTT
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. C. CROOKE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

AMIR, S., BARKER, S., BUTT, W. et al. Gonadotrophin-inhibiting Action of Certain Carbohydrates. Nature 211, 975–976 (1966). https://doi.org/10.1038/211975a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/211975a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing