Abstract
CONSIDERABLE differences in the radioactivity of carbondioxide expired by liver slices of mother and foetal rats, after incubation with l-14C-L-glutamate, indicated a lower enzymatic activity of the L-glutamic-dehydrogenase (GDH) of the foetal liver compared with the adult liver1. The low activity of a large number of enzymes in foetal organs is known, but the oxidative enzymes generally are an exception, and usually show a higher activity in foetal than in maternal organs (for a comprehensive survey, see ref. 2). An increase in the activity of GDH was observed during foetal development in the central nervous system of pigs and monkeys3.
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References
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KOPPE, P., GOETZE, E. Enzymatic Activity of L-Glutamic Dehydrogenase in Liver Mitochondria of Adult and Foetal Rats. Nature 211, 887–888 (1966). https://doi.org/10.1038/211887a0
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DOI: https://doi.org/10.1038/211887a0
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