Abstract
THE crystal shape of pure human adult haemoglobin (HbA) has unanimously been described as that of well-developed, symmetrical bipyramids1,2. Investigations of the crystal forms of human foetal haemoglobin (HbF), however, have revealed divergent results: hexagonal rhombic plates3, probably monoclinic forms4 and a mixture of dodecahedra and square prisms5 have been reported. All these investigations were carried out on cord blood. Our methods allow the investigation of pure crystalline foetal haemoglobin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Perutz, M. F., Nature, 150, 324 (1942); Nature, 160, 786 (1947).
Drabkin, D. L., Arch. Biochem., 21, 224 (1949).
Haurowitz, F., Hoppe-Seyler's Z. physiol. Chem., 232, 125 (1935).
Jope, H. M., and O'Brien, J. R. P., in Haemoglobin, 269, edit. by Roughton, F. J. W., and Kendrew, J. C. (Butterworths Scientific Publications, London, 1949).
Zinsser, H. H., and Tang, Y. C., Arch. Biochem. Biophys., 34, 81 (1951).
Betke, K., Marti, H. R., and Schlicht, I., Nature, 184, 1877 (1959).
Chernoff, A. I., Blood, 8, 399 (1953).
Jope, E. M., in Haemoglobin, edit. by Roughton, F. J. W., and Kendrew, J. C., 205 (Butterworths Scientific Publications, London, 1949).
Taylor, J. F., and Swarn, R. L., Fed. Proc., 8, 259 (1949).
Smithies, O., Biochem. J., 61, 629 (1955).
Chernoff, A. I., and Pettit, jun., N. M., J. Lab. Clin. Med., 63, 290 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STÖFFLER, G., FLOHÉ, L. & TISCHENDORF, F. Large-scale Crystallization of Purified Human Foetal Oxyhaemoglobin from Cord Blood. Nature 211, 768–769 (1966). https://doi.org/10.1038/211768b0
Issue Date:
DOI: https://doi.org/10.1038/211768b0
This article is cited by
-
Die Glutathionperoxidase: Enzymologie und biologische Aspekte
Klinische Wochenschrift (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
