Abstract
IT is well known that the administration of endotoxin results in a very rapid increase in size of the reticuloendothelial system (RES)1. The RES is enhanced not only quantitatively but also qualitatively, in that radio-actively labelled endotoxin is more rapidly removed by the RES of animals which have previously received endotoxin2. Tritiated endotoxin administered subcutaneously is found initially in the intraendothelial cells of the lymphoid channel, and the sinusoidal cells of the draining lymph node. By 24 h the large mononuclear cells, infiltrating the area, contain the labelled material3. In a similar fashion, labelled antigens (such as non-endotoxin) which are administered subcutaneously localize in the macrophages of the medullary sinuses and the lymphoid follicles of the draining lymph nodes4. They are also more rapidly and avidly taken up by immune and immunologically tolerant animals5.
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OPPENHEIM, J., WOLFF, S. Cellular Localization of Carbon-14 Endotoxin in Cultured Leucocytes. Nature 211, 767–768 (1966). https://doi.org/10.1038/211767a0
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DOI: https://doi.org/10.1038/211767a0
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