Abstract
MOORE and Puriton1 in an early report in the literature state that small doses of ox adrenal extract reduce the blood pressure of the dog, but large doses increase it. The same observations have been reported by Cannon and Lyman2 and by Dale and Richards3. This depressor response is not to be confused with that noted after the injection of larger doses of adrenaline or splanchnic nerve stimulation in the presence of α-adrenergic blocking agents such as dibenamine4. The latter observation is now explained on the basis of the unopposed stimulation of β-adrenergic receptors based on the receptor classification of Ahlquist5.
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References
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MCCARTY, L., CHENOWETH, M. Cholinergic Mechanism of Depressor Response to Small Doses of Adrenaline. Nature 211, 750–751 (1966). https://doi.org/10.1038/211750a0
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DOI: https://doi.org/10.1038/211750a0
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