Abstract
BROMOSULPHTHALEIN (phenoltetrabromophthalein disulphonate sodium) is metabolized by organisms and forms a conjugate with glutathione1–4. Rose bengal (tetrachlortetraiodofluorescein), which resembles bromosulphthalein in structure, does not form similar conjugates but undergoes partial deiodination in the organism5–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Krebs, J. S., and Brauer, W., Amer. J. Physiol., 194, 37 (1958).
Combes, B., and Stakelum, G. S., J. Clin. Invest., 39, 1214 (1960).
Javitt, N. B., Wheeler, H. O., Baker, K. J., Ramos, O. L., and Bradley, S. E., J. Clin. Invest., 39, 1570 (1960).
Hoenig, V., Klinika a patofysiologie jaterní chromosekrece (SZN Praha, 1963). (Clinical and Pathophysiological Aspects of Chromosecretion by the Liver.)
Kubin, R. H., Grodsky, G. M., and Carbone, J. V., Proc. Soc. Exp. Biol. and Med., 104, 650 (1960).
Jirsa, M., Čs. Pharmacie, 11, 357 (1962).
Raban, P., and Jirsa, M., Nature, 195, 1100 (1962).
Tubis, M., Nordyke, R. A., Posnick, E., and Blahd, W. H., J. Nucl. Med., 2, 282 (1961).
Jureček, M., Organická Analysa, 2, 140 (ČSAV Praha, 1957).
Combes, B., J. Clin. Invest., 38, 1426 (1959).
McMillion, C. R., and Dunning, H. A. B., J. Amer. Pharm. Assoc., Sci. ed., 48, 249 (1959).
Jureček, M., Organická Analysa, 1, 280 (ČSAV Praha, 1955).
Pratt, D. S., Doane, F. B., and Harvey, A. W., J. Amer. Chem. Soc., 41, 1289 (1919).
Beyer, H., Organická Chemie (SNTL, Praha, 1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JIRSA, M., HYKEŠ, P. Preparation, Properties and Metabolism of Iodinated Bromosulphthalein. Nature 211, 645–646 (1966). https://doi.org/10.1038/211645a0
Issue Date:
DOI: https://doi.org/10.1038/211645a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.