Abstract
THE four antigenetically different heavy polypeptide chain sub-types1–3 of γG-globulin* are probably determined by genes at different genetic loci4–7. Two of these, the ‘We’ and ‘Vi’ loci, are closely linked and related to the Gm system4–7. Gm1 and Gm4 are alleles belonging to the ‘We’ locus. Myeloma proteins or isolated γG-antibodies of the We sub-group are Gm(1) or Gm(4) (refs. 4 and 8). Gm5 belongs to the ‘Vi’ locus where various partly identical genes are present9. Isolated γG-antibodies of the Vi sub-group are either Gm(5) or lack any known Gm factor4–6. It has been suggested that Gm(−5) antibodies of the Vi sub-group are determined by a hypothetical unidentified gene Gm−, which is the true allele of Gm5 (refs. 4 and 6).
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NATVIG, J. Gm(g)—A “New” Gamma-globulin Factor. Nature 211, 318–319 (1966). https://doi.org/10.1038/211318a0
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DOI: https://doi.org/10.1038/211318a0
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