Abstract
ALTHOUGH detailed information concerning the substrate specificity1,2, co-factor requirement and physico-chemical properties2 of L-amino-acid oxidase is available, our knowledge of the mechanisms of the reactions catalysed by this enzyme leaves much to be desired. Radda3 has recently proposed a mechanism for the oxidation of phenylglycines by L-amino-acid oxidase which involves the elimination of the α-hydrogen as a hydride ion (or radical) followed by hydrolysis of the imine and dissociation of the enzyme-product complex.
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TRIGGLE, D., MORAN, J. Rate-determining Step in the Action of L-Amino-acid Oxidase. Nature 211, 307–308 (1966). https://doi.org/10.1038/211307a0
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DOI: https://doi.org/10.1038/211307a0
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