Abstract
IT has been recently found that when 2-acetylaminofluorene (AAF) and several other carcinogenic amines are administered to rats, N-hydroxylation of the compound occurs in vivo1,2. Using AAF, or several other amines, it has been shown that the N-hydroxy metabolite (N—OH—AAF) was a more active carcinogen than the parent compound3.
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Cramer, J. W., Miller, J. A., and Miller, E. C., J. Biol. Chem., 235, 885 (1960)
Boyland, E., Dukes, C. E., and Grover, P. L., Brit. J. Cancer, 17, 79 (1963).
Miller, E. C., Miller, J. A., and Hartmann, H. A., Cancer Res., 21, 815 (1961).
Miller, J. A., and Miller, E. C., Ann. N.Y. Acad. Sci., 123, 125 (1965).
Della Porta, G., Terracini, B., Dammert, K., and Shubik, P., J. Nat. Cancer Inst., 25, 573 (1960).
Miller, J. A., Enomoto, M., and Miller, E. C., Cancer Res., 22, 1381 (1962).
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GOODALL, C., GASTEYER, S. Skin Tumours and Sarcomata induced in Rats by N-Hydroxy-2-acetylaminofluorene. Nature 211, 1422 (1966). https://doi.org/10.1038/2111422a0
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DOI: https://doi.org/10.1038/2111422a0
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