Abstract
ACCORDING to the present genetic theory, parental (P) strain cells transplanted to an F1 hybrid introduce no foreign antigen to the host, incite no homograft response, and survive indefinitely. This has been shown experimentally with P→F1 skin grafts. Some P-strain tumour cells, however, have been shown to grow poorly in F1 hybrids1; and transplants of antibody-forming and haemopoietic cells from certain P strains fail to grow in F1 hybrids at a rate comparable to that seen in isologous controls2,3. One of the puzzling features of this phenomenon is the fact that morphologically intact P→F1 skin grafts survive even in strain combinations where grafts of dissociated cells fail.
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GOODMAN, J., WHEELER, H. Modification of Poor Growth of Parental Marrow Cells in F1 Hybrid Mice. Nature 211, 1420–1421 (1966). https://doi.org/10.1038/2111420a0
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DOI: https://doi.org/10.1038/2111420a0
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