Abstract
BROOME1,2 suggested that L-asparaginase is responsible for the antilymphoma activity of guinea-pig serum3. We confirmed the hypothesis4 and furthermore presented5 evidence that extracts of Escherichia coli B contain an asparaginase which also has high antilymphoma activity. This communication presents evidence that the regression of lymphosarcoma 6C3HED induced by L-asparaginase is preceded by an increase in the alkaline ribonuclease of the post-mitochondrial cell fraction of the tumour, while the acid ribonuclease of that fraction is increased later during the regression.
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MASHBURN, L., WRISTON, J. Change in Ribonuclease Concentrations in L-Asparaginase-treated Lymphosarcomata. Nature 211, 1403–1404 (1966). https://doi.org/10.1038/2111403a0
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DOI: https://doi.org/10.1038/2111403a0
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