Abstract
THE presence of a fibrous component in amyloid first detected in 1959 by the electron microscopic studies of Cohen and Calkins1 has been confirmed by all subsequent observers. The fibrillar structure of amyloid, its physico-chemical properties and its exclusive occurrence in the extra-cellular portion of the connective tissue suggested that amyloid is a variant of one of the normal fibrous proteins2,3. We believe that the following observations are pertinent to this hypothesis.
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References
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MERKER, HJ., SHIBOLET, S., SOHAR, E. et al. Periodic Cross-banding in Amyloid Filaments. Nature 211, 1401–1402 (1966). https://doi.org/10.1038/2111401a0
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DOI: https://doi.org/10.1038/2111401a0
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