Abstract
LYMPHOID cells from a highly inbred parental strain of rat injected into F1 hybrids derived from that strain and another inbred strain provoke a reaction, characterized among other manifestations by a hyperplasia of the recipients' spleen and other lymphoid tissues1. A striking splenic enlargement can also be produced in the chick embryo by intravenous injection of adult chicken spleen cells, or peripheral white blood cells2. The splenomegaly in both instances is due to an attack by the inoculated immunologically competent cells directed against a host incapable of reacting against them3–5. The splenomegaly is part of a more generalized graft versus host (GVH) reaction and reduction of the degree of splenomegaly is therefore a measure of the inhibition of the GVH reaction6,7.
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FIELD, E., GIBBS, J., TUCKER, D. et al. Effect of Thalidomide on the Graft versus Host Reaction. Nature 211, 1308–1310 (1966). https://doi.org/10.1038/2111308a0
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DOI: https://doi.org/10.1038/2111308a0
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